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KMID : 0616120110420040366
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 4 p.366 ~ p.370
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Effects of Bee Venom on Propionibacterium acnes-induced inflammatory Skin Disease in Mice
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Lee Woo-Ram
Park Ji-Hyun
Kim Kyung-Hyun
An Hyun-Jin
Han Sang-Mi
Park Kwan-Kyu
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Abstract
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Bee venom (BV) has been used as a treatment for a wide variety of ailments such as inflammatory diseases in korean traditional medicine. Despite its well documented anti-inflammatory property, it has not been fully demonstrated regarding the influence of BV against Propionibactierium acnes (P. acnes), which promotes follicular inflammation (inflammatory acne). This study evaluated the anti-inflammatory property of BV against P. acnes in vivo. To induce inflammation in vivo using P. acnes, 1×10? CFU of living P. acnes were intradermally injected into the ear of mice. BV (1, 10, 100 μg) in vaseline was applied epicutaneously on the ear resulting in P. acnes-induced ear swelling and inflammation. Epicutaneous administration of BV with P. acnes decreased the number of infiltrated inflammatory cells and inflammatory cytokines in the ear, thereby relieving P. acnes-induced ear swelling and granulomatous inflammation, especially at the dose of 1 μg of BV. In this report, we demonstrated the therapeutic effects of BV on P. acnes-induced inflammation in vivo using the mouse model. These data highlight the potential of using BV as an alternative treatment to the antibiotic therapy of acne vulgaris.
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KEYWORD
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Bee venom, Propionibactierium acnes, inflammation, cytokine, skin
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